Fasano was brought to America at the age of three by her parents. She received her art training in New York at the Cooper Union and the Art Students League, in Rome with Arturo Dazzi, and in Paris at the Academies Colarossi and Julian. She taught art at the Dalton School, New York, and at Mahattanville College of the Sacred Heart, Purchase, New York. She was been married in 1936 to fellow sculptor and Academician, Jean de Marco.
Fasano began exhibiting her work at the Academy in the 1930s. She made a specialty of small religious and allegorical sculptures, working especially in terra-cotta. She also wrote on sculptural techniques. Among her numerous honors were the Academy's Daniel Chester French Medal, awarded in the annual exhibition of 1965, and the Dessie Greer Prize, awarded in 1968. She was a member of the National Sculpture Society, Audubon Artists, and the Sculptor's Guild.
