Wickwire, a portraitist and painter of still life, was descended from a long line of Yankee farmers. His father was a steel magnate. He was educated at Philips Academy (ABG: you note: Andover or Exeter) and graduated from Yale in 1907. In 1908 he married Constant Lowesbury Johnson. He then studied at the Art Students League with Mora and Bellows and later with Chase.
Exhibitions of his work were held at Reinhart Gallery, New York (1939), the Syracuse Museum of Fine Arts (1941); Demotte Gallery, Washington, DC (1947) and Doll and Richards Gallery, Boston (1953). In 1954 he spent six weeks in Toledo, Spain painting and studying his favorite artists, El Greco, Goya and Velasquez.